====== Applied researches ====== \\ \\ {{:icbfm:science:биосет_оборудование_для_синтеза_днк.jpg?direct&100 |}} **Equipment for DNA/RNA synthesis** \\ \\ **Innovative devices to synthesize natural and modifed DNA/RNA-olygonucleotides have been developed and produced. ** \\ \\ \\ \\ \\ \\ \\ \\ {{:icbfm:science:ихбфм_биочипы.jpg?direct&100 |}} **Biochip to detect viral pathogenes** \\ \\ **Universal microchip to define all known strains of influenza type A on the base the essential genes - hemagglutinin (HA) and neuraminidase (NA)- has been designed.** \\ \\ \\ \\ \\ \\ \\ \\ {{:icbfm:science:ихбфм_выявление_патогенов.jpg?direct&100 |}} **Detection of pathogenes carried by ticks** \\ \\ **In 1988 there were first time established the full-length nucleotide sequence of tick-borne encephalitis viral genome (10 487 bp) and characterized its genes in the ICBFM.** \\ \\ \\ \\ \\ \\ \\ \\ {{:icbfm:science:ихбфм_новые_препараты.jpg?direct&100 |}} **New medications for treatment of tick-borne encephalitis** \\ \\ **A therapeutic antibody against tick-borne encephalitis virus was designed in ICBFM.** **The antibody specifically binds to protein E of the virus with affinnity 10̄¹¹М and is capable of neutralizing infectivity of the different viral strains.** \\ \\ \\ \\ {{:icbfm:science:ихбфм_противоопухолевые_препараты.jpg?direct&100 |}} **Antitumor gene-directed drugs** \\ \\ **//In vivo// studies showed that average life span of animal treated with combined therapy (cyclophosphamide + siRNA) rises to 22.44+ 1,35 from 19,38 + 1, 04 days.** \\ \\ \\ \\ \\ \\ \\ {{:icbfm:science:ихбфм_разработка_новых.jpg?direct&100 |}} **Developing new methods to deliver nucleic acids into cells:** \\ \\ - **Therapeutic nucleic acids (TNA) are promissing tool for selective regulation of gene expression**.\\ - **TNA-delivery vechiles based on polyethylenimine-cholesterine conjugates.**\\ - **TNA-delivery vechiles based on supramolecular complexes, a new transfection way**.\\ \\ \\ \\ {{:icbfm:science:ихбфм_создание_основ.jpg?direct&100 |}} **Laying the foundation for targeted gene modification** \\ **The study enabled to design new generations of antiviral drugs and drugs to break genetic material of malignant cells as well. A new part of physico-chemical biology, which is bioorganic chemistry of nucleic acids duplexes, has been created.** \\ \\ \\ \\ \\ \\ \\ {{:icbfm:science:ихбфм_цнмт.jpg?direct&100 |}} **Center of new medical technologies** \\ \\ **Advanced medical technologies « Molecular genetic approaches to evaluate risk for thrombosis predisposition»** and **«Diagnostic method for embolism risk of lower limb venous thrombosis» has been developed and introduced by ICBFM SB RAS .** \\ \\