Laboratory of Invasive Medical Technologies

Vitalyi V. Morozov
Doc.Med.Sci

Phone: + 7 383 291 81 07, Email

• Development of fundamental approaches to personalization of diagnostics, prevention and treatment of venous thrombosis and thromboembolic complications.
• Study of molecular-genetic basis of varicose veins pathogenesis.
• Investigation of effect of polymorphisms ofhemostasis genes on the risk of venous thrombosis and thromboembolic complications.
• Development of highly informative methods for studying the vascular system, evaluation of venous thrombosis embolic complications using latest ultrasound technologies.
• Effect of endovenous use of high-energy on development of pathological changes in hemostatic system, study of risk of thromboembolic complications after endovenous interventions in patients with congenital thrombophilia.
• Investigation of role of matrix metalloproteinases in development of pathological conditions of the venous system.
• Study of effectiveness of different minimally invasive surgery types (NOTES, SILS Port, laparoscopic technologies) in patients with pathology of abdominal cavity.

• Gene polymorphisms of the hemostatic system, significantly increasing risk of venous thrombosis and thromboembolic complications are identified. [Shevela A.I. et al., Phlebology. 2008. 2(2), 19].
• Personalized approach to long-term therapy with indirect anticoagulants in patients with venous thrombosis and thromboembolic complications based on molecular genetic studies of genes polymorphisms of the warfarin metabolism system are developed. [Shevela A.I. et al., NSU Vestnik: Biology, clinical medicine. 2008. 6(2), 44].
• The integrated ultrasonic method, using elastografic mode for an objective assessment of risk of venous embolic complications was designed and introduced into clinical practice. Significantly higher sensitivity and specificity of this method in comparison with standard ultrasound diagnostic scheme was proved. [Nenarochnov S.V. et al., Fundamental Research. 2011. 10(2), 329].
• It was shown that genetically determined changes of the matrix metalloproteinases MMP-3 activity are associated to significant extent with development of venous wall varicose transformation.
• The algorithm of choice of minimally invasive interventions method (NOTES, SILS Port, laparoscopic technology) for patients with surgical diseases of the abdominal cavity was developed.

1. Mayborodin I.V., Shevela A.I., Morozov V.V., Novikova Ya.V., Matveeva V.A., Drovosekov M.N., Barannik M.I., Marchukov S.V., Kuznetsova I.V. Features of angiogenesis after implantation of polyhydroxyalkanoate films with adsorbed multipotent stromal stem cells of bone marrow origin. Morphology. 2013. 143 (1), 41-47.
2. Mayborodin I.V., Morozov V.V., Novikova Ya.V., Matveeva V.A., Artemjeva L.V., Matveev A.L., Khomenyuk S.V., Marhukov S.V. Introduction of mesenchymal stem cells near the thrombosed vein in the experiment promotes angiogenesis in granulations. Phlebology. 2013. 7(1), 10-16.
3. Sevostjanova K.S., Shevela A.I., Novikova Y.V., Tulupov A.A. Possibilities of magnetic resonance imaging in the diagnosis of venous pathology. NSU Vestnik, series: biology, clinical medicine, 2013. 11(3), 212-219.
4. Novikova Ya.V. Trombophilies. Ethiology and pathogenesis. Markers of trombophilic states. Chapter 4. Base of Clinical Phlebology (2nd Edition). Eds. Shevchenko Yu.L., Stoyko Yu.M., Lytkina M.I. JSC “Shiko”. Moscow. 2013, 146-170.
5. Kuznetsova I.V., Shevela A.I., Morozov V.V., Novikova Y.V., Marchukov S.V., Sevostyanova K.S., Mayborodin I.V. Experimental models of venous thrombosis and the possibility of cell-based technologies for the correction of thrombotic conditions. Phlebology. 2012. 6 (1), 43-47.
6. Tsvetovskaya G.A., Chikova E.D., Koch N.V., Lifshitz G.I., Morozov V.V., Novikova Y.V. Modern methods of the laboratory diagnostics in prevention of recurrent thrombosis. Fundamental research. 2012. 10(2), 353-355.
7. Morozov V.V., Novikova Y.V., Shevela A.I., Novak E.V. Recovery of tissue blood flow in rats after injectcion of multipotent mesenchymal stromal cells in the thrombosed vein. Cell Transplantation and Tissue Engineering. 2012. VI (2), 35-36.
8. Novikova Y.V., Shevela A.I., Morozov V.V., Seryapina Yu.V. Indirect anticoagulants long treatment. The modern solution. Phlebology. 2012. 6 (3), 40-45.
9. Morozov V.V., Nenarochnov S.V., Novikova Y.V., Kulikov V.G., Shevela A.I., Novak E.V. The risk of venous thromboembolism: the possibilities of modern ultrasonic methods. Phlebology. 2012. 2(2), 131-132.
10. Mayborodin I.V., Morozov V.V., Novikova, Y.V., Matveeva V.A., Artemyeva L.V., Matveev A.L., Homenyuk S.V., Marchukov S.V. Restoration of microcirculation in the thrombosed vein region after mesenchymal stem cells application in the experiment. Phlebology. 2012. 6(3), 31-37.
11. Morozov V.V., Novikova Y.V., Voronina E.N., Shevela A.I. Genetic predicts of the varicose diseases. The results of the pilot study. Phlebology. 2012. 2(2), 47-48.
12. Morozov V.V., Shevela A.I., Novikova Y.V., Sevostyanova K.S., Voronina E.N., Seryapina Yu.V. Genetic risk factors of venous thrombosis in surgical patients. Phlebology. 2012. 2(2), 108.
13. Burleva E.P., Novikova Ya.V., Sevostyanova K.S., Voronina E.N., Belovа A.D. Variants of the clinical course of venous thromboembolic complications associated with hereditary thrombophilia. Phlebology. 2011. 3(5), 58-63.
14. Shevela A.I., Egorov V.A., Sevostyanova K.S., Novikova Y.V., Filipenko M.L., Thrombosis of deep veins and congenital thrombophilia. Angiology and Vascular Surgery. 2011. 5, 95-99.
15. Nenarochnov S.V., Novikova Y.V., Kulikov V.G., Morozov V.V., Novak E.V. Method to evaluate the risk of venous thrombosis embolism using ultrasound elastografic mode. Fundamental research. 2011. 10 (2), 329-332.

Interdisciplinary integration projects of the Presidium of SB RAS (2012-2014)

• N.142 «Remote monitoring of the cardiovascular activity of the person on the basis of miniature wireless sensors and individual funds with built-in mobile computing facilities»
• N.121 «Comparative studies of articulatory bases of indigenous peoples of Siberia with methods of magnetic resonance imaging, digital radiography and high resolution laryngoscopy»

Partner integration projects of the Presidium of SB RAS (2012-2014)

• N.40 «Development of new approaches in medical functional diagnosis based on the precise registration of the dynamic responses of blood vessels and the thermal response of a new generation of thermal imagers»
  

• Assisted Surgery Equipment «Storz» (Germany),
• anesthesia machines «Dräger» (Germany),
• electrosurgical generators «ForceTriad» «LigaSure» (Valleylab, Switzerland),
• laser devices for Endovasal interventions «IRE-Polus» (Russia) and «Helios II» (Russia),
• ultrasound machines «Toshiba Nemio XG »(Japan) and «Sonosite MicroMaxx 180 »(USA),
• a system for fluorescence (photodynamic) diagnosis of malignant tumors PDD (Germany),
• a system for endoscopic ultrasound-based Pentax ultrasound apparatus Hitachi (Japan),
• the device for removal of build in the submucosal layer of the gastrointestinal tract «Storz» (Germany),
• the device for shock-wave therapy in urology and orthopedics Modulith SLK «Storz» (Germany).