Laboratory of Reproductive Problems

Tatyana V. Ovsyannikova
D.Med.Sci.
Phone: +7 383 363 0183,
Email

• Development of diagnostic techniques in assessment of endometrial and follicular factors providing improvement of results of auxiliary reproductive technologies, and creation of new therapy techniques using cellular and molecular technologies. Study of immune violations mechanisms in women with infertility, research dedicated to possible ways of correction of this disease.
• Development and introduction to practice of new software products at the preparation for IVF cycles.
• Identification of microcenosis infectious agents of uterine cavities in patients with chronic endometritis.
• Study of genes mutation and polymorphisms responsible for synthesis of various compartments which regulate processes of conception, infertility.

• It was proved experimentally and clinically that previous inflammation of genitals reduced number of implantation sites and resulted in infertility. [Kurganov S.A., Popov V.V.Problems of reproduction. 2009.15 (6), 29-33].
• Specific criterion of serological diagnosis of uterine tubes factor is estimated: values of later antibody titers to chlamidya ≥ 1:10. Evaluation of correlation of titers with outcomes of pregnancy attacks??? after plastic and reconstructive surgeries. [Mahotin A.A., Mahotina N.E. NSU Vestnik: biology, clinic medicine. 2009. 7(2), 69].
• Set of genetic screening, algorithm of diagnostics of hereditary and acquired thrombophilic conditions, treatment protocols, monitoring of hematologist is developed. Correlation of identified mutations with clinical status and laboratory parameters in pregnant women is determined. [Cvetovskaa G.A., et al., fundamental research. 2010.10, 72-79].
• On the basis of clinical and laboratory features of infertility in women without blocking factors we develop therapy schemes using efferent methods and cell technologies. [Pasman N.M. et al., The 13th World Congress on Controversies in Obstetrics, Gynecology & Infertility (COGI). The German Society of Obstetrics & Gynecology. 2010. p. A-17; Khonina N. et al., NSU Vestnik. 2010. 8(4), 36-41].

1. Seledtsova N.V., Honina N.A., Tikhonova M.A., Ovsyannikova T.V. Features of distribution of regulatory T-cells at different stages of the reproductive process for women in health and disease. Russian journal of immunology. 2013. 7 (2-3), 284.
2. Honina N.A., Seledtsova N.V. Dynamics of CD4 + CD25 + CD127-specific regulatory T-cells in peripheral blood and endometrium of fertile and infertile women. Russian journal of immunology. 2013. 7(2-3), 286.
3. Korostyshevskaya A.M., Makogon A.V., Savelov A.A., Tkacheva E.G., Shatokha Yu.V., Karpov M.A., Andryushina I.V. The role of MRT in the prenatal diagnosis of spinal malformations. Beam diagnostics and therapy. 2013. 1, 85-92.
4. Khonina N.A., Seledtsova N.V., Shevela A.I., Ovsyannikova T.V., Chernykh E.R. Тh1/Тh2 Content E.r. cytokines in menstrual and peripheral blood in different phases of the menstrual cycle. Russian journal of immunology. 2012.6(2), 187-188.
5. Seledtsova N.V., Khonina N.A., Tikhonova M.A., Ovsyannikova T.V., Chernykh E.R. Regulatory t cells in women with different activity blocking factor in the dynamics of the menstrual cycle. Russian journal of immunology. 2012.6 (2), 153-155.
6. Khonina N.A., Seledtsova N.V., Tikhonova M.A., Ovsyannikova T.V., Chernykh E.R. Content of regulatory t-cells in the peripheral blood and endometrial tissue in dynamics of the menstrual cycle. Bulletin ESSC SB RAMS. 2012.85 (3-2), 208-211.
7. Makogon A.V., Pikalov I.V., Andryushina I.V. Activity of natural anticoagulants fruit 23-29 weeks gestation. Questions of Gynecology, Obstetrics and Perinatology. 2012.11 (5), 56-60.
8. Korostyshevskaya A.M., Makogon A.V., Savelov A.A., Tkacheva E.G., Shatokha Yu.V., Karpov M.A., Andryushina I.V. Features ray methods in early prenatal diagnosis of diastematomielya (case of clinic). Siberian Bulletin of medicine. 2012.11 (5), 53-57.
9. Makogon A.V., Andryushina I.V. Diagnosis and treatment of hemolytic disease of the fetus. Obstetrics and Gynecology. 2012.1, 43-48.
10. Seledtsova N.V., Khonina N.A., Tikhonova M.A., Ovsyannikova T.V., Chernykh E.R. dependence of BF activity and content of NK cells from peripheral blood hormone levels in women with infertility. Med. immunol. 2011. 4-5, 438.
11. Dergachaeva T.I., Borodin Yu.I., Konenkov V.I., Kurganov S.A. The functional State of the lymph vessels, depending on the severity of the inflammatory process of the small pelvis. Journal of lymphology. 2011. 2, 36-42.

During Laboratory’ studies were supported by the Grants of Integration projects of the Presidium of SB RAS, and of the Presidium of RAS.

• Leica DM 5000 microscope (Leica Microsystems, Germany);
• laminar flow hood;
• thermostats;
• CO2 incubators;
• cryodepository;
• centrifuge;
• ultrasound scanners.